Journal: bioRxiv
Article Title: BAY 11-7082 potentiates select β-lactams to inhibit growth of methicillin-resistant Staphylococcus aureus
doi: 10.64898/2026.01.13.699313
Figure Lengend Snippet: A. MRSA expresses five PBPs, PBP1, PBP2, PBP2A (pink), PBP3, and PBP4. B. FICI values calculated based on MRSA USA300 grown in the presence of BAY 11-7082 and another antibiotic. FICI values <0.5 represent synergy, values between 0.5-4 represent no interaction, and values >4 represent antagonism. C. FICI values for MRSA USA300 (pink) and MSSA ATCC 29213 (blue) grown in the presence of BAY 11-7082 and a β-lactam that synergizes with BAY 11-7082 in MRSA. Data represent an average of three independent experiments performed in triplicate.
Article Snippet: We conducted checkerboard assays with MRSA strain USA300, which has mecA ( , Figure S2 ), as well as methicillin-sensitive S. aureus (MSSA) strain ATCC 29213, which does not, to understand the potential role of PBP2a ( , Figure S3 ).
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